Medical Device Qualified Supplier Directory

 

Coated Stent Delivery of DNA (plasmids) - rabbit clinical

Metallic stents coated with a polyurethane emulsion containing plasmid DNA were implanted in rabbit iliac arteries to evaluate transgene delivery and expression in the vessel wall. The expression of the plasmid-encoded marker genes, β-galactosidase, luciferase and green fluorescence protein (GFP), were evaluated at 7 days after implantation. In all cases plasmid transfer was confined to the vessel wall at the site of stent implantation, plasmid DNA was not observed in vessel segments immediately proximal or distal to the stent and dissemination of plasmid DNA to lung, liver or spleen was not observed.


Download
Log in to use your Qmed Profile information. Don't have a Qmed Profile? Register Now.
 
Close
DOWNLOAD FILE
* sorry this is a required field
 
Share Via Email
 

Coatings2Go LLC/Surface Solutions Laboratories, Inc.

www.coatings2go.com
E: [email protected]
T: (978) 369-7411
F: (978) 371-9940

Address
399 Concord St., Carlisle, MA, 01741, United States
View map

 
 

Coatings2Go LLC/Surface Solutions Laboratories, Inc.

www.coatings2go.com
E: [email protected]
T: (978) 369-7411
F: (978) 371-9940

Address
399 Concord St., Carlisle, MA, 01741, United States
View map