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Coated Stent Delivery of DNA (plasmids) - rabbit clinical
Metallic stents coated with a polyurethane emulsion containing plasmid DNA were implanted in rabbit iliac arteries to evaluate transgene delivery and expression in the vessel wall. The expression of the plasmid-encoded marker genes, β-galactosidase, luciferase and green fluorescence protein (GFP), were evaluated at 7 days after implantation. In all cases plasmid transfer was confined to the vessel wall at the site of stent implantation, plasmid DNA was not observed in vessel segments immediately proximal or distal to the stent and dissemination of plasmid DNA to lung, liver or spleen was not observed.
E: [email protected]
T: (978) 369-7411
F: (978) 371-9940
399 Concord St., Carlisle, MA, 01741, United States